10 exam-style questions with answers and explanations, straight from our 1,035-question bank. Tap an answer to check yourself. When you're ready, take the scored version in the free practice test.
The AOCNP exam has 165 questions and runs 3 hours.
These 10 free AOCNP questions are organized by exam domain, so you can see how each part of the Advanced Oncology Certified Nurse Practitioner blueprint is tested. Reveal the answer and explanation under each question.
A 58-year-old with newly diagnosed non-small cell lung cancer has tissue testing that returns positive for an EGFR exon 19 deletion. The APRN explains that this result is MOST useful because it:
Correct answer: A - Predicts likely response to EGFR tyrosine kinase inhibitor therapy
A woman reports that her mother and maternal aunt had breast cancer before age 45 and her maternal grandfather had pancreatic cancer. The APRN recognizes that the MOST appropriate next step is to:
Correct answer: C - Refer her for hereditary cancer genetic counseling and risk assessment
During treatment planning for a 29-year-old man about to begin a gonadotoxic chemotherapy regimen, the APRN's PRIORITY discussion before therapy begins is:
Correct answer: D - Fertility preservation options such as sperm banking
A patient completing curative therapy for stage II colon cancer asks what a survivorship care plan will include. The APRN explains that its two essential components are:
Correct answer: A - A treatment summary and a follow-up surveillance plan
A patient who has received several cycles of an anthracycline-based regimen is being evaluated before the next cycle. The APRN is MOST concerned about which cumulative dose-related toxicity?
Correct answer: B - Cardiomyopathy leading to heart failure
Three weeks after starting an immune checkpoint inhibitor (anti-PD-1), a patient develops six loose stools per day with abdominal cramping. After ruling out infection, the APRN recognizes this MOST likely represents immune-mediated colitis and that first-line management is:
Correct answer: C - Systemic corticosteroids with holding of the checkpoint inhibitor
A patient is receiving a chemotherapy regimen classified as highly emetogenic. To prevent chemotherapy-induced nausea and vomiting, the MOST appropriate prophylaxis is a combination regimen that includes:
Correct answer: A - A 5-HT3 antagonist, an NK-1 antagonist, and dexamethasone
A patient with cancer pain is stable on scheduled oral morphine but must be transitioned to an equianalgesic dose of oral hydromorphone because of intolerable side effects. When calculating the new dose, the APRN applies incomplete cross-tolerance by:
Correct answer: C - Reducing the calculated equianalgesic dose by roughly 25 to 50 percent
A patient is enrolled in a Phase I oncology clinical trial. The APRN explains that the PRIMARY purpose of a Phase I trial is to:
Correct answer: C - Determine safety and the maximum tolerated dose
On day 8 after an allogeneic hematopoietic stem cell transplant, a patient develops a maculopapular rash on the palms and soles, watery diarrhea, and a rising bilirubin. The APRN recognizes these findings as MOST consistent with:
Correct answer: B - Acute graft-versus-host disease
The AOCNP exam also covers these domains. Drill them in the full free practice test:
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